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The anti-VSV intrinsic activity of PMLIV is independent of IRF3, STAT1 and IFN and can be observed during the whole duration of the experiments. In parallel, PMLIV enhances IFN-β mRNA synthesis around 12 h post-infection. This produced IFN is secreted between 18 and 24 h and then acts on other cells by activating STAT1, increasing the expression ISG products thus protecting them from uncoming infection.
