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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Acta Biomater. 2013 Aug 2;10(4):1588–1600. doi: 10.1016/j.actbio.2013.07.031

Fig. 4.

Fig. 4

GSH-responsive PEG-LMWH hydrogels via reversible maleimide–thiol Michael-type addition. i)Conversion of retro-Michael adducts formed with Michael donors of different reactivity. ii) Schematic representation of the formation and degradation of GSH-responsive PEG-LMWH hydrogels. iii) Comparison of storage moduli for select degrading hydrogels: PEG–SH hydrogel (★) LMWH–PEG–MPP (●) and –DMMPP (■) under high reducing conditions (10mM GSH) and LMWH–PEG–MPP (○) under standard reducing conditions (10μM GSH). Reprinted with permission from [90], copyright (2011) American Chemical Society and [91], copyright (2013) The Royal Society of Chemistry.