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Intracellular delivery of reducible heparin nanogels for apoptotic cell death. i) Synthetic scheme of disulfide crosslinked heparin nanogels. ii) (A) Dose-dependent anti-proliferative effect of heparin nanogels against mouse melanoma B16F10 cells after 3 days; (B) Growth profiles of B16F10 cells cultured in the presence of heparin or heparin nanogels. Reprinted with permission from [114], copyright (2008) Elsevier.
