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. Author manuscript; available in PMC: 2014 Feb 27.
Published in final edited form as: Virology. 1998 Aug 15;248(1):139–147. doi: 10.1006/viro.1998.9254

Fig. 1.

Fig. 1

Effects of cyclosporin A on wild-type and nef-defective HIV-1 infectivity. Viruses were produced by culturing transfected 293T cells in the presence of the indicated concentrations of cyclosporin A. Culture supernatants were assayed for reverse transcriptase activity and their titers determined by infecting P4-2 indicator cells. Panel A: The ordinate values represent the number of infectious units per unit reverse transcriptase activity. R9: wild-type HIV-1; R9ΔN: nef-defective HIV-1. Shown are the mean values of triplicate infections, with error bars representing one standard deviation from the mean. The data are representative of two independent experiments. In Panel B, the data shown in Panel A are represented as the percentage by which viral infectivity is reduced by the indicated concentrations of CsA.