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. Author manuscript; available in PMC: 2014 Feb 27.
Published in final edited form as: Virology. 1998 Aug 15;248(1):139–147. doi: 10.1006/viro.1998.9254

Fig. 6.

Fig. 6

Cyclosporin A inhibits replication of mutant HIV-1 lacking CyPA. CEM cells were inoculated with aliquots of viruses containing 30,000 cpm reverse transcriptase activity. After overnight culturing, the cells were pelleted to remove input virus, and cultured in 2 ml media in the presence (dashed lines) and absence (solid lines) of 2.5 µM CsA. Virus production was monitored periodically by assaying for reverse transcriptase activity in the supernatants. Panel A: wild-type HIV-1; C: HIV-1 containing a mutation of Pro222 to Ala in capsid; E: HIV-1 containing a mutation of Gly221 to Ala in capsid. Replication of the nef-defective variants of R7, R7.222, and R7.221 are shown in panels B, D, and F, respectively.