Table 2. Pharmacokinetic characteristics of subcutaneous and intravenous palonosetron, compared by Student's t test for paired samples and Wilcoxon's test.

	IV	SC	p
	mean (± SD)	Mean (± SD)
AUC0-24h (ng × h/ml)	14.10±6.73	12.68±6.70	0.160
Cmax (ng/ml)	11.88±7.38	1.91±1.09	<0.001
tmax (min) 1	1 (1–10)	15 (10–32)	<0.001*
ke (h−1)	0.095±0.117	0.075±0.061	0.527 *
t1/2 (h)	12.71±10.21	14.68±9.79	0.527 *
C12h (ng/ml)	0.487±0.292	0.459±0.289	0.671
C24h (ng/ml)	0.415±0.206	0.414±0.235	0.365
Ae24h (%)	19.48±9.99	22.24±8.50	0.660

IV: intravenous. SC: subcutaneous. AUC_0–24h: area under the plasma drug concentration-time curve between 0 to 24 hours. n.s.s: non statistically significant. C_max: maximum concentration. t_max: time to maximum concentration. k_e: elimination constant t_1/2: half life. C: concentration. A_e: amount of palonosetron eliminated by urine.

*: Wilcoxon's test.

¹: Median and range.