Table 2. The type of a cancer gene and its probability-weighted times of starting an order with a probability greater than random chance.
Gene | Type | Times | Rate | Gene | Type | Times | Rate |
TP53 | s | 484.732 | 0.844 | XPO1 | o | 1 | 0.077 |
APC | s | 117.471 | 0.675 | TIF1 | o | 1 | 0.125 |
PIK3CA | o | 31.97 | 0.381 | ERCC5 | s | 1 | 0.083 |
MLL3 | s | 26.927 | 0.481 | ELN | o | 1 | 0.125 |
KRAS | o | 24.093 | 0.223 | LRIG3 | o | 1 | 0.167 |
MLL2 | s | 20.235 | 0.355 | LMO1 | o | 1 | 0.5 |
CREBBP | s/o | 17.294 | 0.402 | ASPSCR1 | o | 1 | 1 |
ATM | s | 14.404 | 0.4 | NCOA1 | o | 1 | 0.143 |
ARID1A | s | 13.625 | 0.296 | SRSF2 | o | 1 | 0.5 |
NPM1 | s | 12.96 | 0.48 | CBL | s/o | 1 | 0.2 |
EZH2 | s | 10.733 | 0.335 | MYD88 | o | 1 | 0.125 |
CIC | s | 10.649 | 0.41 | NUP98 | o | 1 | 0.01 |
ARID2 | s | 8.699 | 0.335 | PTPN11 | o | 1 | 0.2 |
ROS1 | o | 7.888 | 0.316 | CDH1 | s | 0.999 | 0.062 |
TET2 | s | 7.049 | 0.441 | PER1 | o | 0.999 | 0.125 |
WT1 | s | 7.027 | 0.502 | MEN1 | s | 0.999 | 0.1 |
CTNNB1 | o | 6.862 | 0.114 | PRDM1 | s | 0.999 | 0.125 |
PBRM1 | s | 6.854 | 0.685 | IL21R | o | 0.998 | 0.25 |
PTEN | s | 6.801 | 0.235 | MUC1 | o | 0.997 | 0.332 |
BRAF | o | 5.988 | 0.23 | PIK3R1 | s | 0.997 | 0.066 |
NOTCH2 | o | 5.907 | 0.281 | TRIP11 | o | 0.996 | 0.1 |
MYST4 | o | 5.492 | 0.25 | ITK | o | 0.995 | 0.059 |
SMARCA4 | s | 5.45 | 0.156 | NCOA2 | o | 0.995 | 0.199 |
DNMT3A | s | 5.293 | 0.23 | BCOR | s | 0.995 | 0.059 |
ASXL1 | s | 5.064 | 0.362 | TSHR | o | 0.995 | 0.124 |
MYH9 | o | 4.988 | 0.416 | MAP2K4 | s | 0.994 | 0.076 |
KDM5A | o | 4.987 | 0.623 | GNAS | o | 0.994 | 0.062 |
NSD1 | o | 4.965 | 0.414 | MSH2 | s | 0.993 | 0.199 |
MYH11 | o | 4.561 | 0.198 = = = | SRGAP3 | o | 0.993 | 0.165 |
BCL2 | o | 4.165 | 0.116 | FGFR2 | o | 0.992 | 0.142 |
RET | o | 3.991 | 0.333 | FANCD2 | s | 0.991 | 0.33 |
EP300 | s | 3.991 | 0.174 | MET | o | 0.991 | 0.099 |
ALK | o | 3.972 | 0.306 | EWSR1 | o | 0.991 | 0.142 |
PHF6 | s | 3.264 | 0.297 | BRIP1 | s | 0.99 | 0.165 |
BLM | s | 3.076 | 0.22 | SETD2 | s | 0.99 | 0.062 |
IDH2 | o | 3 | 0.214 | BCL6 | o | 0.989 | 0.11 |
COL1A1 | o | 2.997 | 0.231 | WHSC1 | o | 0.985 | 0.123 |
GNA11 | o | 2.996 | 0.749 | BAP1 | s | 0.983 | 0.089 |
SF3B1 | o | 2.993 | 0.136 | ETV6 | o | 0.953 | 0.136 |
TPR | o | 2.987 | 0.373 | FLI1 | o | 0.902 | 0.18 |
CDH11 | o | 2.987 | 0.187 | DNM2 | s | 0.89 | 0.064 |
PDGFRA | o | 2.971 | 0.186 | BCR | o | 0.888 | 0.296 |
MLL | o | 2.847 | 0.142 | VHL | s | 0.818 | 0.055 |
KIT | o | 2.59 | 0.173 | FANCC | s | 0.711 | 0.711 |
MED12 | o | 2.514 | 0.168 | MAF | o | 0.682 | 0.341 |
FBXW7 | s | 2.428 | 0.069 | RUNX1 | o | 0.65 | 0.043 |
RB1 | s | 2.204 | 0.092 | CARD11 | o | 0.5 | 0.019 |
LIFR | o | 2.175 | 0.128 | LHFP | o | 0.5 | 0.167 |
AKAP9 | o | 2.156 | 0.108 | NUMA1 | o | 0.453 | 0.032 |
NRAS | o | 2.037 | 0.06 | SUZ12 | o | 0.397 | 0.066 |
EGFR | o | 2 | 0.154 | KIAA1549 | o | 0.319 | 0.106 |
JAK2 | o | 2 | 0.2 | NCOA4 | o | 0.314 | 0.157 |
PALB2 | s | 1.991 | 0.153 | FHIT | o | 0.257 | 0.086 |
NF1 | s | 1.989 | 0.071 | TNFAIP3 | s | 0.254 | 0.023 |
JAK1 | o | 1.986 | 0.397 | NFKB2 | o | 0.22 | 0.11 |
PRDM16 | o | 1.97 | 0.246 | MDM4 | o | 0.198 | 0.066 |
CAMTA1 | o | 1.703 | 0.122 | H3F3A | o | 0.197 | 0.197 |
NOTCH1 | o | 1.681 | 0.06 | HIP1 | o | 0.196 | 0.028 |
CCND2 | o | 1.628 | SUFU | s | 0.188 | 0.047 | |
SMARCB1 | s | 1.601 | 0.543 | SBDS | s | 0.184 | 0.092 |
NF2 | s | 1.5 | 0.133 | JAK3 | o | 0.144 | 0.013 |
FOXP1 | o | 1.5 | 0.3 | HOOK3 | o | 0.11 | 0.026 |
CD74 | o | 1.499 | 0.15 | TCF7L2 | o | 0.094 | 0.006 |
CCND3 | o | 1.404 | 0.75 | EIF4A2 | o | 0.069 | 0.007 |
PIM1 | o | 1.402 | 0.14 | ERBB2 | o | 0.06 | 0.003 |
SLC45A3 | o | 1.384 | 0.175 | ZNF331 | o | 0.052 | 0.013 |
IL7R | o | 1.27 | 0.154 | C15orf55 | o | 0.046 | 0.011 |
BTG1 | o | 1.174 | 0.159 | HOXA11 | o | 0.045 | 0.015 |
ZNF521 | o | 1.148 | 0.196 | PHOX2B | s | 0.018 | 0.006 |
PDE4DIP | o | 1.099 | 0.057 | PCM1 | o | 0.008 | 0.002 |
MSH6 | s | 1.017 | 0.061 | MALT1 | o | 0.003 | 0.001 |
LMO2 | o | 1 | 0.17 | Total | 1034.4 |
s: tumor-suppressor gene, o: oncogene. The ratios of the summed frequencies of s, o, and s/o to the total are 0.775, 0.207 and 0.018, respectively.
Rate is the ratio of Times to the gene's total mutation number in the samples in question.