Skip to main content
. 2014 Feb 27;9(2):e89244. doi: 10.1371/journal.pone.0089244

Table 2. The type of a cancer gene and its probability-weighted times of starting an order with a probability greater than random chance.

Gene Type Times Rate Gene Type Times Rate
TP53 s 484.732 0.844 XPO1 o 1 0.077
APC s 117.471 0.675 TIF1 o 1 0.125
PIK3CA o 31.97 0.381 ERCC5 s 1 0.083
MLL3 s 26.927 0.481 ELN o 1 0.125
KRAS o 24.093 0.223 LRIG3 o 1 0.167
MLL2 s 20.235 0.355 LMO1 o 1 0.5
CREBBP s/o 17.294 0.402 ASPSCR1 o 1 1
ATM s 14.404 0.4 NCOA1 o 1 0.143
ARID1A s 13.625 0.296 SRSF2 o 1 0.5
NPM1 s 12.96 0.48 CBL s/o 1 0.2
EZH2 s 10.733 0.335 MYD88 o 1 0.125
CIC s 10.649 0.41 NUP98 o 1 0.01
ARID2 s 8.699 0.335 PTPN11 o 1 0.2
ROS1 o 7.888 0.316 CDH1 s 0.999 0.062
TET2 s 7.049 0.441 PER1 o 0.999 0.125
WT1 s 7.027 0.502 MEN1 s 0.999 0.1
CTNNB1 o 6.862 0.114 PRDM1 s 0.999 0.125
PBRM1 s 6.854 0.685 IL21R o 0.998 0.25
PTEN s 6.801 0.235 MUC1 o 0.997 0.332
BRAF o 5.988 0.23 PIK3R1 s 0.997 0.066
NOTCH2 o 5.907 0.281 TRIP11 o 0.996 0.1
MYST4 o 5.492 0.25 ITK o 0.995 0.059
SMARCA4 s 5.45 0.156 NCOA2 o 0.995 0.199
DNMT3A s 5.293 0.23 BCOR s 0.995 0.059
ASXL1 s 5.064 0.362 TSHR o 0.995 0.124
MYH9 o 4.988 0.416 MAP2K4 s 0.994 0.076
KDM5A o 4.987 0.623 GNAS o 0.994 0.062
NSD1 o 4.965 0.414 MSH2 s 0.993 0.199
MYH11 o 4.561 0.198 =  =  =  SRGAP3 o 0.993 0.165
BCL2 o 4.165 0.116 FGFR2 o 0.992 0.142
RET o 3.991 0.333 FANCD2 s 0.991 0.33
EP300 s 3.991 0.174 MET o 0.991 0.099
ALK o 3.972 0.306 EWSR1 o 0.991 0.142
PHF6 s 3.264 0.297 BRIP1 s 0.99 0.165
BLM s 3.076 0.22 SETD2 s 0.99 0.062
IDH2 o 3 0.214 BCL6 o 0.989 0.11
COL1A1 o 2.997 0.231 WHSC1 o 0.985 0.123
GNA11 o 2.996 0.749 BAP1 s 0.983 0.089
SF3B1 o 2.993 0.136 ETV6 o 0.953 0.136
TPR o 2.987 0.373 FLI1 o 0.902 0.18
CDH11 o 2.987 0.187 DNM2 s 0.89 0.064
PDGFRA o 2.971 0.186 BCR o 0.888 0.296
MLL o 2.847 0.142 VHL s 0.818 0.055
KIT o 2.59 0.173 FANCC s 0.711 0.711
MED12 o 2.514 0.168 MAF o 0.682 0.341
FBXW7 s 2.428 0.069 RUNX1 o 0.65 0.043
RB1 s 2.204 0.092 CARD11 o 0.5 0.019
LIFR o 2.175 0.128 LHFP o 0.5 0.167
AKAP9 o 2.156 0.108 NUMA1 o 0.453 0.032
NRAS o 2.037 0.06 SUZ12 o 0.397 0.066
EGFR o 2 0.154 KIAA1549 o 0.319 0.106
JAK2 o 2 0.2 NCOA4 o 0.314 0.157
PALB2 s 1.991 0.153 FHIT o 0.257 0.086
NF1 s 1.989 0.071 TNFAIP3 s 0.254 0.023
JAK1 o 1.986 0.397 NFKB2 o 0.22 0.11
PRDM16 o 1.97 0.246 MDM4 o 0.198 0.066
CAMTA1 o 1.703 0.122 H3F3A o 0.197 0.197
NOTCH1 o 1.681 0.06 HIP1 o 0.196 0.028
CCND2 o 1.628 SUFU s 0.188 0.047
SMARCB1 s 1.601 0.543 SBDS s 0.184 0.092
NF2 s 1.5 0.133 JAK3 o 0.144 0.013
FOXP1 o 1.5 0.3 HOOK3 o 0.11 0.026
CD74 o 1.499 0.15 TCF7L2 o 0.094 0.006
CCND3 o 1.404 0.75 EIF4A2 o 0.069 0.007
PIM1 o 1.402 0.14 ERBB2 o 0.06 0.003
SLC45A3 o 1.384 0.175 ZNF331 o 0.052 0.013
IL7R o 1.27 0.154 C15orf55 o 0.046 0.011
BTG1 o 1.174 0.159 HOXA11 o 0.045 0.015
ZNF521 o 1.148 0.196 PHOX2B s 0.018 0.006
PDE4DIP o 1.099 0.057 PCM1 o 0.008 0.002
MSH6 s 1.017 0.061 MALT1 o 0.003 0.001
LMO2 o 1 0.17 Total 1034.4

s: tumor-suppressor gene, o: oncogene. The ratios of the summed frequencies of s, o, and s/o to the total are 0.775, 0.207 and 0.018, respectively.

Rate is the ratio of Times to the gene's total mutation number in the samples in question.