Figure 3. Comparison of sequence patterns in TK-specific motifs.

A. Sub-domains of the protein kinase domain. Consensus sequences DL(R/A)A(A/R)N in subdomain VI and XP(I/V)(K/R)W(T/M)APE in subdomain VIII are specific to TKs. The motif in red [GXR(M/L)] was identified in this study. The motif CW(X)₆RPXF in gray was found to be not specific to TKs in this study (Figure S2). B. The LOGOs show sequence patterns of the three motifs in each group. Red arrow heads indicate conserved amino acid residues that are diagnostic for TKs.