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. 2014 Feb 22;14:119. doi: 10.1186/1471-2407-14-119

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Copyright © 2014 Lehn et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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YAP1 mRNA predicts outcome in molecular subgroups of primary breast cancer. (a) YAP1 mRNA expression was dichotomised at the median value to generate high and low YAP1 expressing groups. Low YAP1 mRNA correlates to a decreased recurrence-free survival in the entire dataset. (b) YAP1 mRNA quartiles of the ER+ subgroup (n = 700) correlates to a decreased recurrence-free survival whereas the trend in the (c) ER- subgroup (n = 239) is opposite but not significant. (d-h) Survival analyses in breast cancer molecular subgroups. Low YAP1 mRNA is associated with decreased recurrence-free survival in the luminal A but not luminal B, HER2, basal or normal-like subgroups. Q = quartile, RFS = recurrence-free survival.