Table 1.
Correlations of YAP1 protein expression and clinical and molecular parameters of the screening cohort (n=144)
| |
All patients, n=144 |
|
ER
+
patients, n=125 |
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| |
YAP1 intensity, n=117 |
|
YAP1 intensity, n=99 |
|
||||||
| |
Absent |
Weak |
Intermediate |
Strong |
|
Absent |
Weak |
Intermediate |
Strong |
|
|
n (%) |
n (%) |
n (%) |
n (%) |
p-value |
n (%) |
n (%) |
n (%) |
n (%) |
p-value |
|
| Variable | 4 (3) | 52 (44) | 38 (33) | 23 (20) | 4 (4) | 46 (47) | 35 (35) | 14 (14) | ||
| NHG |
|
|
|
|
|
|
|
|
|
|
| I |
0 |
3 (6) |
6 (16) |
2 (9) |
|
0 |
3 (7) |
6 (17) |
2 (14) |
|
| II |
2 (50) |
26 (50) |
19 (50) |
9 (41) |
|
2 (50) |
25 (54) |
19 (54) |
9 (64) |
|
| III |
2 (50) |
23 (44) |
13 (34) |
11 (50) |
0.646a |
2 (50) |
18 (39) |
10 (29) |
3 (21) |
0.060a |
| Lymph node status |
|
|
|
|
|
|
|
|
|
|
| Negative |
1 (25) |
26 (52) |
22 (65) |
12 (63) |
|
1 (25) |
23 (51) |
20 (63) |
10 (83) |
|
| Positive |
3 (75) |
24 (48) |
12 (35) |
7 (37) |
0.128b |
3 (75) |
22 (49) |
12 (37) |
2 (17) |
0.022b |
| Tumour size |
|
|
|
|
|
|
|
|
|
|
| <20 mm |
0 |
26 (50) |
18 (47) |
9 (41) |
|
0 |
24 (55) |
18 (51) |
8 (57) |
|
| ≥20 mm |
4 (100) |
26 (50) |
20 (53) |
13 (59) |
0.995b |
4 (100) |
22 (45) |
17 (49) |
6 (43) |
0.347b |
| ERα |
|
|
|
|
|
|
|
|
|
|
| <10% |
0 |
6 (12) |
3 (8) |
8 (36) |
|
- |
- |
- |
- |
|
| ≥10% |
4 (100) |
46 (88) |
35 (92) |
14 (64) |
0.030b |
- |
- |
- |
- |
|
| PgR |
|
|
|
|
|
|
|
|
|
|
| <10% |
1 (25) |
17 (33) |
9 (24) |
14 (64) |
|
1 (25) |
12 (26) |
6 (17) |
6 (43) |
|
| ≥10% |
3 (75) |
35 (67) |
29 (76) |
8 (36) |
0.084b |
3 (75) |
34 (74) |
29 (83) |
8 (57) |
0.691b |
| Ki-67 fraction (%) |
|
|
|
|
|
|
|
|
|
|
| 0-10 |
0 |
0 |
3 (8) |
2 (10) |
|
0 |
0 |
3 (9) |
2 (15) |
|
| 11-25 |
2 (67) |
20 (44) |
18 (49) |
7 (33) |
|
2 (67) |
18 (45) |
18 (53) |
6 (46) |
|
| 26-100 |
1 (33) |
25 (56) |
16 (43) |
12 (57) |
0.626a |
1 (33) |
22 (55) |
13 (38) |
5 (39) |
0.091a |
| Cyclin D1 intensity |
|
|
|
|
|
|
|
|
|
|
| Negative/Low |
0 |
19 (51) |
20 (67) |
12 (86) |
|
0 |
17 (53) |
17 (63) |
6 (75) |
|
| Moderate/High | 4 (100) | 18 (49) | 10 (33) | 2 (14) | 0.002b | 4 (100) | 15 (47) | 10 (37) | 2 (25) | 0.040b |
NHG=Nottingham histological grade, ER=estrogen receptor, PgR=progesterone receptor.
aSpearman´s rank correlation.
bMann-Whitney U test.