Table 4.
The difference in treatment response between patient groups of different YAP1 expression is significant: A multivariate Cox proportional hazards regression analysis for YAP expression and treatment interaction based on ER+ breast cancer patients*
| |
|
Recurrence-free survival |
|
|
|---|---|---|---|---|
| Variable | Category | HR | 95% CI | P value |
| YAP1 expression |
Weak, intermediate or strong |
1.00 |
|
|
| |
Absent |
1.42 |
0.56 to 3.59 |
0.456 |
| Treatment |
Control |
1.00 |
|
|
| |
Tamoxifen |
0.42 |
0.26 to 0.68 |
<0.001 |
| Interaction variable† | Tamoxifen x YAP1 expression | 3.51 | 1.05 to 11.75 | 0.042 |
*Other factors included in the analysis are tumour grade (NHG I + II vs. III), nodal status (negative vs. positive) and tumor size (≤ 20 mm vs. >20 mm).
†Interaction variable states if there is a difference in the treatment response in relation to YAP1 expression.
HR = Hazard ratio, CI = Confidence interval, NHG = Nottingham histological grade.