Table 1. Concentration of cytokines (log pg/ml) in venous blood and hematoma fluid samples.
| Cytokine | Venous blood | Hematoma fluid | N | Mean difference | ||
| N | Mean (SD) | N | Mean (SD) | (95% CI), p-value | ||
| Pro-inflammatory cytokines | ||||||
| IL-1β | 51 | 1.4 (0.7) | 43 | 1.3 (0.7) | 41 | 0.2 (0.0–0.4), 0.082 |
| IL-2 | 50 | 0.8 (0.8) | 45 | 0.7 (0.5) | 45 | 0.2 (0.0–0.4), 0.113 |
| IL-7 | 55 | 1.5 (0.3) | 56 | 1.7 (0.2) | 54 | −0.3 (−0.3–−0.2), <0.001B |
| IL-6 | 41 | 1.1 (0.8) | 41 | 3.8 (0.9) | 31 | −2.8 (−3.2–−2.4), <0.001B |
| CCL2 (MCP-1) | 56 | 2.3 (0.4) | 53 | 3.5 (0.5) | 52 | −1.2 (−1.4–−1.0), <0.001B |
| CXCL9 (MIG) | 55 | 1.5 (0.4) | 54 | 1.9 (0.6) | 53 | −0.3 (−0.5–−0.1), 0.001B |
| TNF-α | 41 | 0.6 (0.5) | 38 | 0.5 (0.5) | 36 | 0.2 (0.1–0.3), 0.002B |
| IL-12 | 57 | 2.0 (0.3) | 56 | 1.9 (0.3) | 56 | 0.0 (−0.1–0.2), 0.394 |
| IL-2R | 57 | 2.4 (0.3) | 56 | 2.8 (0.3) | 56 | −0.3 (−0.5–−0.2), <0.001B |
| IL-15 | 57 | 1.8 (0.4) | 56 | 1.9 (0.4) | 56 | −0.1 (−0.2–0.0), 0.157 |
| CXCL10 (IP-10) | 57 | 1.6 (0.4) | 51 | 2.5 (0.5) | 51 | −0.9 (−1.0–−0.8), <0.001B |
| IL-17 | 29 | 1.2 (0.7) | 45 | 1.3 (0.6) | 27 | −0.3 (−0.6–0.0), 0.031 |
| CXCL8 (IL-8) | 52 | 0.9 (0.5) | 56 | 3.3 (0.9) | 51 | −2.5 (−2.8–−2.2), <0.001B |
| Anti-inflammatory cytokines | ||||||
| IL-4 | 57 | 1.5 (0.5) | 56 | 1.1 (0.4) | 56 | 0.4 (0.3–0.5), 0.001B |
| IL-5 | 40 | 1.0 (0.4) | 50 | 1.4 (0.6) | 38 | −0.4 (−0.6–−0.1), 0.003 |
| IL-10 | 57 | 1.0 (0.5) | 56 | 1.4 (0.4) | 56 | −0.3 (−0.5–−0.2), <0.001B |
| IL-1RA | 57 | 2.7 (0.5) | 56 | 2.7 (0.5) | 56 | 0.0 (−0.1–0.2), 0.522 |
| IL-13 | 43 | 0.9 (0.5) | 53 | 1.4 (0.5) | 43 | −0.4 (−0.7–−0.2), <0.001B |
B)
Statistically significant after Bonferroni correction of multiple testing.