Table 1.

Trial stages for all families and children

Time	Start	Day medication starts	1 week after medication starts	2 weeks after medication starts	3 weeks after medication starts	4 weeks after medication starts	12 weeks after medication starts	52 weeks after medication starts
Study discussed in clinic	X
Consent	X
Randomisation	X
Local Paediatrician: medication prescribed	X
Trial Research Paediatrician: medication started		phone call
Trial Research Paediatrician: medication dose adjustments			phone call	phone call	phone call	phone call	phone call	phone call
Adverse effects assessed
Trial Outcome Assessor: primary and secondary outcome measures		phone call				phone call	phone call	phone call
remaining medication returned							X