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SREBP-1 silencing does not improve whole body glucose or insulin tolerance. Mice were treated as described in Fig. 2. A, glucose and insulin levels in serum; n = 5–8. B, glucose tolerance test (GTT) conducted after overnight fast and intraperitoneal administration of a glucose bolus (1 mg/g body weight). An insulin tolerance test (ITT) was carried out after fasting animals for 5 h and intraperitoneal administration of human regular insulin (1 unit/kg); n = 7 db/db, n = 5 WT.
