TABLE 1.
Effect of SREBP-1 silencing on weight and serum chemistries
Mice were treated as described in the legend of Fig. 2. *, p < 0.05 db/db gAd.shSREBP1 versus gAd.shSCR; **, p < 0.05 compared with WT. n = 8 db/db, n = 4–5 WT.
|
db/db |
WT gAd.shSCR | ||
|---|---|---|---|
| gAd.shSCR | gAd.shSREBP | ||
| Total body weight (g) | 44.7 ± 1.92** | 40.3 ± 3.65*,** | 22.7 ± 1.32 |
| Feda | |||
| Liver weight (g) | 2.63 ± 0.22 | 1.83 ± 0.18* | 1.10 ± 0.06 |
| Serum FFAs (mm) | 1.55 ± 0.27** | 2.23 ± 0.28*,** | 0.96 ± 0.06 |
| Serum TG (mg/ml) | 1.17 ± 0.27** | 1.41 ± 0.44** | 0.75 ± 0.06 |
| Fasted | |||
| Liver weight (g) | 2.18 ± 0.20 | 1.46 ± 0.16* | 0.86 ± 0.05 |
| Serum FFAs (mm) | 1.32 ± 0.22 | 2.05 ± 0.14*,** | 1.25 ± 0.1 |
| Serum TG (mg/ml) | 0.63 ± 0.08 | 1.01 ± 0.11*,** | 0.74 ± 0.1 |
a FFA, free fatty acid; TG, triglyceride.