FIGURE 9.

Representative cross-link depicting an intra- versus intermolecular contact between the N- and C-terminal residues in the monomer versus dimer of apoA-IV. a, the monomeric non-MDSA simulated model for full-length apoA-IV is shown in green. The α-carbons of Lys residues 59 and 330 are shown as red spheres and are connected in an intramolecular cross-link as indicated in Table 2. b, the non-MDSA model was used to generate a preliminary model of the dimeric form of full-length apoA-IV as shown with molecule A in green and molecule B in teal. The same Lys residues are shown participating in an intermolecular cross-link.