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Model for the cell cycle synchronization by mimosine. Mimosine treatment synchronizes cells at the G1/S phase boundary by blocking the activation of the pre-RC. Mimosine treatment strongly activates ATM-mediated cell cycle checkpoint signaling, which prevents cells from entering S phase. In contrast, thymidine treatment synchronizes cells after the initiation of DNA replication and activates the S phase checkpoint. Pre-IC, preinitiation complex.
