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Rheb levels are decreased in AD prefrontal cortex. A, representative Western blot of BACE1 and Rheb in AD versus control samples. B, quantitative analysis of the Western blots showed that Rheb levels are significantly reduced, whereas BACE1 levels significantly increased in AD groups relative to control group (n = 10/group, ***, p < 0.001, *, p < 0.05 versus control, Student's t test). C, Rheb reduction is correlated to BACE1 increase in AD and not in control group.
