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. 2013 Dec 23;289(9):5828–5845. doi: 10.1074/jbc.M113.478495

FIGURE 3.

FIGURE 3.

A, CP55,940-induced [35S]GTPγS binding in F3.36200A mutant hCB1R cells, when applied alone (DMSO) or in the presence of ORG27569 (1 μm). B, effect of ORG27569 alone on [35S]GTPγS basal binding in WT and F3.36200A hCB1 cells. C, CP55,940-induced [35S]GTPγS binding in W6.48356A mutant hCB1R cells, when applied alone (DMSO) or in the presence of ORG27569 (1 μm). D, effect of ORG27569 alone on basal [35S]GTPγS binding in WT and W6.48356A hCB1 cells. Symbols represent mean values ±S.E. from three to six experiments carried out in duplicate. Effect of CP55940 is expressed as a percentage of the Emax value of CP55940 in the presence of vehicle.