KLF15 is regulated in physiological and pathological conditions.
A, Klf15, Ep300, Pdk4, and Fatp1 expression in mouse heart during fed, fasted (24 h), and refed (24 h of fasting followed by 24 h of refeeding). n = 5. *, p < 0.05 versus Fed. **, p < 0.05 versus fasted. B, Klf15, Ep300, Pdk4, Fatp1, Glut4, and Glut1 expression in mouse heart during postnatal maturation (n = 4). *, p < 0.05 versus day 1. C, KLF15 expression in fetal versus adult human heart tissue (n = 3–4). p < 0.05. D, KLF15 expression in human hearts that are non-failing, with advanced heart failure (prior to LVAD placement), and post-LVAD placement (n = 3–4). *, p < 0.05 versus non-HF. **, p < 0.05 versus Pre-LVAD. Rodent values are normalized to cyclophilin-B (Ppib) and human values to 18 S rRNA. Error bars, S.E.