FIGURE 8.
WT Syn-1A inhibition of KATP channels is resistant to other phospholipids. Representative KATP channel current tracings of SUR1 + Kir6.2 + Syn-1A-WT-expressing HEK293 cells, control (A) or treated with 10 μm phosphatidylcholine (B), phosphatidyl-l-serine (C), or inositol 1,4,5-trisphosphate (IP3) (D) in the pipette solution. E, summary showing no difference in current densities between control cells (n = 7) and each of the phospholipid-treated cells (phosphatidylcholine, n = 6; phosphatidyl-l-serine, n = 6; IP3, n = 6). Results are means ± S.E. (error bars); NS, not significant.