FIGURE 2.

Inhibition of HCV replication by inhibitors of PI4KA. HCV replication was tested as described previously (33). A shows a tight correlation between the potencies of drugs against PI4KA and inhibition of HCV replication using two different HCV strains (r² = 0.758, p < 0.0001, and r² = 0.797, p < 0.0001, for HCV1A and HCV1B, respectively). B shows that no correlation was found with the PI4KB potencies and HCV replication with the same set of compounds (r² = 0.149, p = 0.114, and r² = 0.057, p = 0.341, for HCV1A and HCV1B, respectively). Compounds selected for future analysis are labeled in A.