Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jan 10;289(9):6120–6132. doi: 10.1074/jbc.M113.531426

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 9. — Histochemical analysis of selected segments of the GI track in wild-type and conditional pi4ka knock-out (cPI4KO) mice after tamoxifen treatment. Hematoxylin-eosin staining of the glandular stomach, duodenum, ileum jejunum, cecum, and colon. Panels a versus g, note the degeneration/necrosis of glandular pit, foveolar, and neck epithelial cells and lamina propria edema. Cellular debris is present within gastric pits in the cPI4KO animals. Panels b and c versus h and i, note the degeneration/necrosis of enterocytes on the villi and within intestinal crypts, crypt regeneration/hyperplasia (increased mitoses and cytoplasmic basophilia), and lamina propria edema in the cPI4KO animals both in the duodenum and ileum. Similar pathologies were observed in the jejunum, cecum, and colon (shown in panels d, e, and f versus panels j, k, and l).