FIGURE 5.

Raman difference spectra of OXA-1 or OXA-24 single crystal reaction with penem 1. A, Raman difference spectrum of OXA-1 and penem 1 at 3, 15, and 30 min in the presence of PEG 8000. A control spectrum of penem 1 (upper trace) was first recorded in the presence of PEG. After penem 1 was soaked in, the spectra were taken at the above indicated time points. B, Raman difference spectrum of OXA-24 and penem 1 at 4, 15, and 30 min in the presence of PEG 2000. A control spectrum of penem 1 (upper trace) was first recorded in the presence of PEG. After penem 1 was soaked in, the spectra were taken at the above indicated time points.