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Altered metabolic parameters in adipo-ERK5−/− mice. Oxygen consumption (VO2) (A), carbon dioxide production (VCO2) (B), respiratory quotient (RER) (C and D), energy expenditure (Heat) (E), food intake (F), meal number (G), and meal size (H) of 12-week-old adipo-ERK5−/− and control mice (n = 8) were determined by an indirect open circuit calorimeter system. Locomotor activity (I and J) of the adipo-ERK5−/− and control mice were also shown. *, p < 0.05; #, p < 0.005. Error bars, S.E.
