Table 2. Model comparisons using Bayes factors (likelihood ratios of two competing models) and biological interpretations.

Genotype	BF ± 1 SE	Interpretation of BF
A. Immune response required? Comparing hybrid   model with Mideo et al. (2008b) model:
AS + DK	(5.5 ± 3.0) × 1052	Immune responses required to explain data
B. Age-structure required? Comparing hybrid   model with Miller et al. (2010) model:
AS + DK	.44 ± .08	Age structure not required to explain data
C. Removal of extra death rate for multiply   parasitized RBCs:
AS + DK	(1.1 ± .2) × 1016	Increased death rate required to explain data
D. Removal of immune-mediated merozoite clear-   ance from model:
AS	(1.1 ± 1.1) × 1016	Decisive evidence of clearance of AS merozoites
DK	1.0 ± .1	No evidence of clearance of DK merozoites
E. Removal of immune-mediated parasitized RBC   clearance from model:
AS	3.6 ± .4	Some evidence of parasitized RBC clearance
DK	2.8 ± .7	Some evidence of parasitized RBC clearance
F. Removal of immune-mediated unparasitized   RBC clearance from model:
AS	4.9 ± .5	Some evidence of unparasitized RBC clearance
DK	.40 ± .05	No evidence of unparasitized RBC clearance

Note: Values are Bayes factors (BF) ± 1 standard error of the BF. A, Original model from Mideo et al. (2008b) versus hybrid model incorporating age structure and immunity. B, C, Comparisons of hybrid model with reduced versions. D–F, Effects of removing key immune components from hybrid model. RBC = red blood cell.