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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Transl Stroke Res. 2013 Jun 7;4(5):515–523. doi: 10.1007/s12975-013-0266-1

Fig. 4.

Fig. 4

Behavioral recovery after stroke in aged. Behavioral recovery in aged animals following photothrombosis stroke was assessed on grid-walking (panels a and b) and cylinder/forelimb asymmetry (panel c) tasks. Analysis of forelimb (a) and hindlimb (b) footfaults revealed a significant increase in the number of foot faults compared with baseline measurements 1 week post-stroke. Daily IP administration of DV (2 mg/kg) resulted in a significant decrease in the number of forelimb and hindlimb footfaults made when DV was given 3 h post-stroke. Assessment of forelimb asymmetry using the cylinder task (c) showed that the mice had a greater tendency to spend more time on their left forepaw post-stroke when pressing against the cylinder wall as revealed by an increase in the left/right ratio after stroke. Daily IP administration of DV (2 mg/kg) resulted in a significant improvement in the use of the impaired right forelimb when DV was given 3 h post-stroke. An n=7 per group were used for these studies. +=P<0.05, ++=P<0.01 compared with stroke+vehicle-treated controls