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. 2014 Mar 1;127(5):1138–1149. doi: 10.1242/jcs.145052

Fig. 8.

Fig. 8.

Deafness and cochlear pathology of wl/wl mutant mice. Representative trace of ABR recording for (A) WT and (B) wl/wl mice using 16 kHz stimulus frequencies at P50. Note the lack of typical ABR peaks in wl/wl mutant animals. (C) ABR thresholds (dB SPL) of wl/wl mutant mice and non-mutant controls tested at 35–63 days of age (n = 4). Error bars represent s.d. of the threshold means. (D–G) Cross sections through the basal turn of the cochlea from a normal heterozygous mouse (D,F) and a wl/wl mutant mouse (E,G) examined at 2 months of age. Note the decreased density of spiral ganglion cells (SGC) in the wl/wl cochlea. Outer hair cells and inner hair cells appear normal. SGC, spiral ganglion cell; OC, organ of Corti; IHC, inner hair cells; OHC, outer hair cells. Scale bars: 100 µm.