Table 3. Meta-analysis of rs2254546 in association with KD risk stratified by study design.
Case-control | TDT | OR (95%CI) | ||||
---|---|---|---|---|---|---|
Study ID | Cases G/A | Controls G/A | Transmitted G | Non-transmitted G | Case-control | TDT |
Onouchi (GWAS), 2012 | 702/154 | 4866/1892 | - | - | 1.77 (1.48–2.13) | - |
Onouchi (CC1), 2012 | 761/179 | 522/234 | - | - | 1.91 (1.52–2.38) | - |
Onouchi (CC2), 2012 | 454/114 | 808/330 | - | - | 1.63 (1.28–2.07) | - |
Onouchi (TDT1), 2012 | - | - | 75 | 60 | - | 1.25 (0.89–1.76) |
Onouchi (TDT2), 2012 | - | - | 24 | 16 | - | 1.50 (0.80–2.82) |
Onouchi (TDT3), 2012 | - | - | 21 | 12 | - | 1.75 (0.86–3.56) |
Onouchi (TDT4), 2012 | - | - | 25 | 19 | - | 1.32 (0.72–2.39) |
Yan, 2013 | 590/126 | 1246/384 | - | - | 1.44 (1.15–1.81) | - |
Current study, 2013 | 664/172 | 724/224 | - | - | 1.19 (0.95–1.50) | - |
Pooled | 3171/745 | 8166/3064 | 145 | 107 | 1.57 (1.34–1.85)† | 1.35 (1.05–1.74)‡ |
†Random-effects pooled OR, P < 0.001; Q = 10.84, Pheterogeneity = 0.028.
‡Fixed-effects pooled OR, P = 0.018; Q = 0.83, Pheterogeneity = 0.843.