Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Quality of life
RCT	40 people aged 14–75 years with primary segmental (16 people) or generalised dystonia (24 people) for a minimum of 5 years	Improvement in short form (SF)-36 physical component score 10.1 with neurostimulation 3.8 with sham stimulation Change in SF-36 physical component score; possible range of scores of 0–100	P = 0.02 33/40 (82.5%) assessed for this outcome	Effect size not calculated	neurostimulation
RCT	40 people aged 14–75 years with primary segmental (16 people) or generalised dystonia (24 people) for a minimum of 5 years	Improvement in SF-36 mental component score 5.2 with neurostimulation 0.2 with sham stimulation Change in SF-36 mental component score; possible range of scores of 0–100	P = 0.39		Not significant
RCT	40 people aged 14–75 years with primary segmental (16 people) or generalised dystonia (24 people) for a minimum of 5 years Further report of reference	Improvement in SF-36 physical function score 3 months 27.3 with neurostimulation 3.0 with sham stimulation	P = 0.001 36/40 (90%) assessed for this outcome	Effect size not calculated	neurostimulation
RCT	40 people aged 14–75 years with primary segmental (16 people) or generalised dystonia (24 people) for a minimum of 5 years Further report of reference	Improvement in SF-36 bodily pain score 3 months 22.7 with neurostimulation 9.7 with sham stimulation	P = 0.04 37/40 (93%) assessed for this outcome	Effect size not calculated	neurostimulation
RCT	40 people aged 14–75 years with primary segmental (16 people) or generalised dystonia (24 people) for a minimum of 5 years Further report of reference	Improvement in SF-36 general health score 3 months 17.6 with neurostimulation 2.1 with sham stimulation	P = 0.02 37/40 (93%) assessed for this outcome	Effect size not calculated	neurostimulation
RCT	40 people aged 14–75 years with primary segmental (16 people) or generalised dystonia (24 people) for a minimum of 5 years Further report of reference	Improvement in SF-36 vitality score 3 months 14.7 with neurostimulation 2.0 with sham stimulation	P = 0.047 37/40 (93%) assessed for this outcome	Effect size not calculated	neurostimulation
RCT	40 people aged 14–75 years with primary segmental (16 people) or generalised dystonia (24 people) for a minimum of 5 years Further report of reference	Improvement in SF-36 role physical score 3 months 25.0 with neurostimulation 13.2 with sham stimulation	P = 0.20 35/40 (88%) assessed for this outcome		Not significant
RCT	40 people aged 14–75 years with primary segmental (16 people) or generalised dystonia (24 people) for a minimum of 5 years Further report of reference	Improvement in SF-36 social function score 3 months 21.1 with neurostimulation 0.7 with sham stimulation	P = 0.07 37/40 (93%) assessed for this outcome		Not significant
RCT	40 people aged 14–75 years with primary segmental (16 people) or generalised dystonia (24 people) for a minimum of 5 years Further report of reference	Improvement in SF-36 role emotional score 3 months 24.6 with neurostimulation 13.7 with sham stimulation	P = 0.43 36/40 (90%) assessed for this outcome		Not significant
RCT	40 people aged 14–75 years with primary segmental (16 people) or generalised dystonia (24 people) for a minimum of 5 years Further report of reference	Improvement in SF-36 mental health score 3 months 10.7 with neurostimulation 2.0 with sham stimulation	P = 0.54 37/40 (93%) assessed for this outcome		Not significant
RCT	40 people aged 14–75 years with primary segmental (16 people) or generalised dystonia (24 people) for a minimum of 5 years Further report of reference	Improvement in Brief Psychiatric Rating Scale 3 months –5.9 with neurostimulation –3.0 with sham stimulation	P = 0.09 37/40 (93%) assessed for this outcome		Not significant