Table 2.
Genes differentially expressed in H. influenzae Eagan at pH 8.0 compared to pH 6.8
| Genes up-regulated at pH 8.0 compared to 6.8 | ||||
|---|---|---|---|---|
|
Metabolic genes | ||||
|
Gene |
Log
2
fold |
p
-value |
FDR |
Comment |
| HI1010 |
2.21 |
5.12×10-10 |
1.02×10-7 |
6-phosphogluconate dehydrogenase |
| HI1011 |
2.20 |
6.83×10-10 |
1.22x10-7 |
Similar to YgbK |
| HI1012 |
2.04 |
3.06×10-8 |
3.64x10-6 |
Sugar isomerase |
| HI1013 |
1.88 |
3.04×10-7 |
2.86×10-5 |
Hydroxypyruvate isomerase |
| HI1014 |
1.52 |
2.33×10-5 |
1.54×10-3 |
Sugar epimerase |
| HI1015 |
1.12 |
1.18×10-3 |
4.70×10-2 |
GntP family, gluconate:H+ symporter |
| HI0091 |
1.74 |
5.98×10-7 |
5.33×10-5 |
Hypothetical protein; homologous to GlxK, glycerate kinase |
| HI0092 |
2.14 |
1.49×10-9 |
2.41×10-7 |
GntP family, gluconate:H+ symporter |
|
Iron uptake genes | ||||
|
Gene |
Log
2
fold |
p
-value |
FDR |
Comment |
| HI0995 |
1.53 |
1.72×10-5 |
1.23×10-3 |
OMP, iron-binding |
|
hitA |
2.21 |
1.69×10-10 |
3.77×10-8 |
Iron uptake |
|
hxuB |
1.65 |
1.54×10-6 |
1.25×10-4 |
Hemopexin utilization protein |
|
hxuC |
1.70 |
8.04×10-7 |
6.83×10-5 |
TonB-dependent heme receptor |
|
Genes of unknown function | ||||
|
Gene |
Log
2
fold
|
p
-value |
FDR |
Comment |
| HI1427 |
1.54 |
6.87×10-6 |
5.33×10-4 |
Hypothetical protein |
|
Genes down-regulated at pH 8.0 compared to 6.8
| ||||
|
Gene |
Log
2
fold |
p
-value |
FDR |
Comment |
| HI1349 |
-2.31 |
5.58×10-11 |
1.42×10-8 |
Ferritin |
| HI1385 | -1.55 | 2.27×10-5 | 1.54×10-3 | FtnB; non-heme ferritin |