Table 3.
Genes differentially expressed in H. influenzae R3264 at pH 8.0 compared to pH 6.8
| Genes up-regulated at pH 8.0 compared to 6.8 | ||||
|---|---|---|---|---|
|
Iron uptake genes | ||||
|
Gene |
Log
2
fold |
p
-value |
FDR |
Comment |
|
hitA |
1.76 |
9.65×10-12 |
2.46×10-9 |
Iron uptake ABC, periplasmic domain |
|
hitB |
1.31 |
8.77×10-7 |
1.11×10-4 |
Iron uptake ABC, permease domain |
|
tbp2 |
1.54 |
2.92×10-5 |
2.74×10-3 |
Iron-binding OM receptor |
|
tbp1 |
1.49 |
3.53×10-7 |
5.26×10-5 |
Transferrin binding protein |
|
h×uB |
1.02 |
8.62×10-5 |
7.32×10-3 |
Heme-hemopexin utilization protein |
|
Metabolic genes | ||||
|
Gene |
Log
2
fold |
p
-value |
FDR |
Comment |
|
glpB |
1.08 |
5.35×10-5 |
4.77×10-3 |
Glycerol metabolism |
|
Genes of unknown function | ||||
|
Gene |
Log
2
fold |
p-value |
FDR |
Comment |
| HI0997 |
1.34 |
8.95×10-4 |
5.51×10-2 |
Hypothetical protein |
| HI1427 |
1.31 |
4.17×10-7 |
5.72×10-5 |
Transmembrane protein |
|
Genes down-regulated at pH 8.0 compared to 6.8
| ||||
|
Gene |
Log
2
fold |
p
-value |
FDR |
Comment |
| HI1349 |
-1.23 |
5.14×10-6 |
5.10×10-4 |
Ferritin |
| ahpD | -1.72 | 1.24×10-7 | 2.01×10-5 | Stress response |