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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Biomaterials. 2014 Jan 22;35(10):3145–3153. doi: 10.1016/j.biomaterials.2014.01.001

Figure 1. Monocyte related cells create “cell based metabolic barriers” (CBMB) to glucose and oxygen diffusion at sites of glucose sensor implantation and compromise CGM.

Figure 1

Based on the literature and recent data from our laboratories, we hypothesized that the recruitment and accumulation of monocyte related cells (i.e. MQ and FBGC) at the sensor-tissue interface create a “Cell Based Metabolic Barrier” (white arrow) to glucose and oxygen that is diffusing from the vasculature (V) toward implanted glucose sensors (sensor).