Table 1.

Dose and schedule

Cohort	No.	Dose (mg/kg)	Schedule
1	1	0.03	Weekly ×4
2	1	0.1	Weekly ×4
3	1	0.3	Weekly ×4
4	3	1.0	Weekly ×4
5	4	3.0	Weekly ×4
6	7	6.0	Weekly ×4
7	8	3.0	Days 1, 3, and 5, then weekly ×3
8	8	10	Cycle 1: 3 mg/kg day 1, 7 mg/kg day 3, then weekly ×3
9	8	15	Cycle 1: 3 mg/kg day 1, 12 mg/kg day 3, then weekly ×3
10	9	20	Cycle 1: 3 mg/kg day 1, 17 mg/kg day 3, then weekly ×3
11	4	6.0	Days 1, 3, and 5, then once per week ×3
12	3	10	Days 1, 3, and 5, then once per week ×3
Expansion	26	10, 20, or 30	Once per week ×8, then once per month ×4

Weekly means once per week. Patients in cohorts 5 through 12 could receive 2 additional 4-week cycles if there was evidence of clinical benefit.