Table 3. Glaucoma Probability Score: Univariate and Multivariable Hazard Ratios for the development of POAG.
| Univariate | Multivariable* | ||
|---|---|---|---|
| Hazard Ratio (95% CI*) | Hazard Ratio (95% CI) | ||
| Outside normal limits versus not outside normal limits | Result | 3.03 (1.67, 5.50) | 2.84 (1.49 5.40)) |
| Global | 3.99 (2.21 7.22) | 3.51 (1.86 6.90) | |
| Nasal | 3.94 (2.18 7.12) | 3.86 (1.86 6.86) | |
| Nasal Inferior | 3.18 (1.66 6.10) | 2.87 (1.42 5.82) | |
| Nasal Superior | 3.32 (1.76 6.26) | 3.05 (1.51 6.15) | |
| Temporal | 3.69 (2.04 6.66) | 3.25 (1.70 6.20) | |
| Temporal Inferior | 3.38 (1.84 6.22) | 3.07 (1.58 5.95) | |
| Temporal Superior | 3.14 (1.66 5.94) | 2.92 (1.46 5.83) | |
| per 10% greater | Global | 1.22 (1.11 1.34) | 1.20 (1.09 1.33) |
| Nasal | 1.22 (1.11 1.33) | 1.20 (1.09 1.33) | |
| Nasal Inferior | 1.22 (1.12 1.34) | 1.21 (1.09 1.33) | |
| Nasal Superior | 1.22 (1.11 1.34) | 1.20 (1.09 1.33) | |
| Temporal | 1.22 (1.11 1.34) | 1.20 (1.09 1.33) | |
| Temporal Inferior | 1.22 (1.10 1.34) | 1.20 (1.08 1.33) | |
| Temporal Superior | 1.22 (1.11 1.33) | 1.20 (1.09 1.32) | |
| Individual components of GPS | rim steepness normalized (GLOBAL) (per 0.8) | 0.49 (0.32 0.75) | 0.54 (0.37 0.78) |
| GPS Maximum cup depth (per 0.1 mm) | 1.29 (1.10 1.51) | 1.34 (1.14 1.58) | |
| GPS Mean cup depth (per 0.02 mm) | 1.47 (1.17 1.84) | 1.51 (1.17 1.94) | |
| GPS cup area (mm2) | 1.10 (0.99 1.22) | 1.11 (0.98 1.26) | |
| Vertical RNFL curvature (per 0.05) | 0.67 (0.54 0.83) | 0.67 (0.54 0.84) | |
| Horitzontal RNFL curvature (per 0.05) | 0.50 (0.38 0.64) | (0.51 (0.38 0.67) | |
Abbreviations: POAG= primary open-angle glaucoma; CI=Confidence Interval
*
Multivariable model contains baseline age, intraocular pressure, visual field pattern standard devision, central corneal thickness with medication status as a time dependent covariate. 64 eyes were excluded from the multivariable analyses due to missing central corneal thickness values.