Figure 1. Skeletal Abnormalities in Hox gene Mutant Mice.

The regions of the skeleton affected in single Hox gene mutants were marked with respect to axial level and location of the respective genes on one of the Hoxa, Hoxb, Hoxc or Hoxd clusters. The template for the drawings was taken from (Rugh, 1968) and relevant references are found in the Legend to Fig. 1. The colors label the regions affected by genes in paralogous group 4 (green), group 5 (red), group 6 (blue), group 7 (yellow), group 8 (purple), group 9 (orange). Abnormalities in the sternum are indicated by bars to the left. Regions affected by more than one mutation contain several colors. No attempt was made to incorporate information on penetrance of an abnormality or the direction (loss or gain of character, rib bifurcation, sternal articulation, etc.). Except for more sacral and posterior lumbar regions, the developmental defects cluster in regions of morphological transitions, the cervico-thoracic and thoracic-lumbar transition as well as the transition between attached and floating ribs. Mid-cervical and mid-thoracic regions are relatively unaffected.

References for the mutants are: Hoxa4 (Horan et al., 1994; Kostic and Capecchi, 1994), Hoxa5 (Jeanotte et al., 1993), Hoxa6 (Kostic and Capecchi, 1994), Hoxa9 (Fromental-Ramain et al., 1996a), Hoxb4 (Ramirez-Solis et al., 1993), Hoxb5 (Rancourt et al., 1995), Hoxb6 (Rancourt et al., 1995); (Kappen, 2000), Hoxb9 (Chen and Capecchi, 1997), Hoxc4 (Boulet and Capecchi, 1996; Saegusa et al., 1996), Hoxc8 (LeMouellic et al., 1992), Hoxc9 (Suemori et al., 1995), Hoxd4 (Horan et al., 1994), Hoxd9 (Fromental-Ramain et al., 1996a).