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. Author manuscript; available in PMC: 2014 Feb 28.
Published in final edited form as: Birth Defects Res B Dev Reprod Toxicol. 2007 Dec;80(6):425–450. doi: 10.1002/bdrb.20136

Figure 2. Regulators of chondrocyte proliferation and maturation.

Figure 2

Transcription factors (blue), cell cycle regulators (purple), cell surface receptors (green), soluble mediators and growth factors (pink), and structural molecules (orange) have all been shown to affect chondrocyte maturation. Sox9 and additional factors are needed to induce the chondrocyte phenotype initially (for references, see text). The effects of other regulators are depicted as interpreted from phenotypes observed in in vivo overexpression or disruption paradigms (see text for details). The receptors for BMPs (Wozney and Rosen, 1998a) signal through Smad proteins (Massague, 1998) at various stages of chondrocyte differentiation and were not listed to reduce complexity of the graph.