Table 5.

Desflurane, but Not Isoflurane, Reduces Human CSF Aβ42 to Tau Ratio at 2, but Not 24, Hours after the Anesthesia

	S (N = 35)	SD (N = 33)	SI (N = 38)	F Values	P Values
Aβ42/Tau—2 h	1.10 ± 0.41	0.83 ± 0.33**	1.02 ± 0.52	6.83	0.001
Aβ42/Tau—24 h	0.91 ± 0.36	0.84 ± 0.37	0.97 ± 0.46	0.13	0.88

The Aβ42 to tau ratio in human CSF is lower following the surgery under SD (N = 33), but not SI (N = 38), compared to S (N = 35) anesthesia group at 2, but not 24, h after the surgery under anesthesia, F = 13.28,

^**P = 0.0003.

Aβ = β-amyloid protein; CSF = cerebrospinal fluid; S = spinal; SD = spinal plus desflurane; SI = spinal plus isoflurane.