Table 11.
Stepwise Regression model for VO2max training response in the HERITAGE Family Study using candidate gene SNPs derived from global skeletal muscle gene expression profiling (RNA predictor) and exercise training-related QTL studies
| Gene (SNP) | Identification method | RNA level correlation | Chr. | Map | partial r2 | Regression model
|
|
|---|---|---|---|---|---|---|---|
| model r2 | p-value | ||||||
| SVIL (rs6481619) | QTL | YES (+) | 10 | 30,022,960 | 0.0411 | 0.0411 | <.0001 |
| SLC22A3 (rs2457571) | RNA predictor | YES (+) | 6 | 160,754,818 | 0.0307 | 0.0718 | 0.0003 |
| NRP2 (rs3770991) | QTL | YES (+) | 2 | 206,363,984 | 0.0224 | 0.0942 | 0.0017 |
| TTN (rs10497520) | QTL | NO | 2 | 179,353,100 | 0.0204 | 0.1146 | 0.0025 |
| H19 (rs2251375) | RNA predictor | YES (+) | 11 | 1,976,072 | 0.0268 | 0.1414 | 0.0004 |
| ID3 (rs11574) | RNA predictor | YES (+) | 1 | 23,758,085 | 0.02 | 0.1615 | 0.0021 |
| MIPEP (rs7324557) | QTL | YES (−) | 13 | 23,194,862 | 0.0163 | 0.1778 | 0.0051 |
| CPVL (rs4257918) | RNA predictor | YES (+) | 7 | 29,020,374 | 0.0179 | 0.1957 | 0.0031 |
| DEPDC6 (rs7386139) | RNA predictor | YES (+) | 8 | 121,096,600 | 0.0112 | 0.2069 | 0.0185 |
| BTAF1 (rs2792022) | RNA Predictor | YES (+) | 10 | 93,730,409 | 0.0125 | 0.2194 | 0.0122 |
| DIS3L (rs1546570) | RNA Predictor | YES (+) | 15 | 64,382,829 | 0.0095 | 0.2289 | 0.0279 |
Modified from Timmons, et al (2010) Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. J Appl Physiol. 108, 1487–1496