Table 4.

Familial aggregation of maximal enzyme activities in the vastus lateralis muscle in a subset of families of Caucasian descent of the HERITAGE Family Study^*

Phenotype	Pretraining			Training Response
	N	F	p	N	F	p
PCr Metabolism
CK	78	6.25	<0.0001	76	3.97	<0.0001
Glycolysis
PHOS	78	6.85	<0.0001	75	2.14	0.0169
HK	78	1.69	0.069	75	4.01	<0.0001
PFK	78	3.83	<0.0001	76	1.85	0.043
GAPDH	78	5.62	<0.0001	76	2.39	0.0072
Oxidative metabolism
CPT	78	2.55	0.0039	75	2.47	0.0058
HADH	78	3.80	<0.0001	76	2.13	0.017
CS	78	1.66	0.076	76	2.73	0.0023
COX	78	3.03	0.0008	76	2.07	0.0213

^*From 19 families encompassing 78 subjects, all Caucasians.

From Rico-Sanz J, Rankinen T, Joanisse DR, Leon AS, Skinner JS, Wilmore JH, Rao DC and Bouchard C. Familial resemblance for muscle phenotypes in the HERITAGE Family Study. Med Sci Sports Exerc 35(8): 1360–1366, 2003, and Corrigendum – Rankinen T, Bouchard C, and Rao DC. Familial Resemblance for Muscle Phenotypes: The HERITAGE Family Study. Med Sci Sports Exerc 37(11): 2017, 2005. Reproduced with permission from Wolters Kluwer Health.