Table 2.
Demographic characteristics of African American family-based study samples
| Kidney diseasea | # APOL1 risk variants | N | Age, years |
African ancestry, % |
BMI, kg/m2 |
Urine ACR, mg/g |
MDRD eGFR, mL/min/1.73 m2 |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Median | Mean (SD) | Median | Mean (SD) | Median | Mean (SD) | Median | Mean (SD) | Median | |||
| No | 0/1 | 340 | 49.5 (13.0) | 50.0 | 0.79 (0.11) | 0.81 | 33.0 (9.1) | 32.0 | 6.7 (6.2) | 4.1 | 99.2 (22.0) | 98.3 |
| 2 | 89 | 48.1 (14.6) | 49.0 | 0.82 (0.10) | 0.83 | 31.5 (8.6) | 30.2 | 6.6 (5.1) | 4.8 | 97.0 (20.6) | 96.0 | |
| All | 429 | 49.2 (13.3) | 50.0 | 0.80 (0.11) | 0.82 | 32.7 (9.0) | 31.5 | 6.7 (6.0) | 4.3 | 98.8 (21.8) | 98.0 | |
| Yes | 0/1 | 136 | 53.6 (12.7) | 55.0 | 0.81 (0.10) | 0.83 | 35.1 (10.9) | 32.8 | 444.9 (1200.0) | 65.7 | 77.2 (30.3) | 76.1 |
| 2 | 43 | 47.1 (13.6) | 49.0 | 0.83 (0.08) | 0.83 | 34.3 (10.3) | 30.7 | 242.5 (287.0) | 89.1 | 81.3 (33.8) | 81.0 | |
| All | 179 | 52.0 (13.2) | 52.0 | 0.82 (0.10) | 0.83 | 34.9 (10.7) | 32.3 | 396.3 (1058.0) | 68.3 | 78.2 (31.1) | 76.8 | |
| Total | 0/1 | 476 | 50.7 (13.0) | 52.0 | 0.80 (0.11) | 0.82 | 33.6 (9.7) | 32.1 | 131.9 (669.9) | 6.5 | 92.9 (26.6) | 93.4 |
| 2 | 132 | 47.8 (14.2) | 49.0 | 0.82 (0.09) | 0.83 | 32.4 (9.2) | 30.5 | 83.5 (196.8) | 7.8 | 91.9 (26.6) | 91.5 | |
| All | 608 | 50.0 (13.3) | 51.0 | 0.80 (0.10) | 0.82 | 33.3 (9.6) | 31.9 | 121.4 (599.9) | 6.9 | 92.7 (26.6) | 93.1 | |
aKidney disease defined as eGFR < 60 mL/min/1.73 m2 and/or urine ACR > 30 mg/g.
BMI, body mass index; ACR, albumin:creatinine ratio; eGFR, estimated glomerular filtration rate.