Table 3.
Top 14 SNPs showing an interaction effect with APOL1 in non-diabetic ESKD
| Chromosome/nearest gene | Position | SNP | OR | P-valuea |
|---|---|---|---|---|
| 1/NPHS2 | 177795549 | rs16854341 | 0.6 | 0.0008 |
| 1/SDCCAG8 | 241564934 | rs2802723 | 1.8 | 0.0005 |
| 7/∼381 kb to POM12IL12 | 52689925 | rs7810220 | 1.4 | 0.03 |
| 7/∼238 kb to PTPRZ1 | 121062464 | rs10253361 | 0.7 | 0.0099 |
| 8/∼174 kb to STC1 | 23942506 | rs1586171 | 1.6 | 0.0108 |
| 8/∼44 kb to TRIB1 | 126563498 | rs4457349 | 0.7 | 0.0057 |
| 9/∼447 kb to TLE4 | 80929505 | rs11138082 | 0.7 | 0.0192 |
| 10/∼175 kb to GPR26 | 125250912 | rs7897598 | 1.3 | 0.0816 |
| 13/ENOX1 | 43050726 | rs9533534 | 0.7 | 0.0022 |
| 13/∼54 kb to SUCLA2 | 47361123 | rs7986369 | 0.7 | 0.0209 |
| 14/LOC728755 | 27053341 | rs12587505 | 0.7 | 0.0274 |
| 14/∼8 kb to BMP4 | 53501324 | rs8014363 | 1.6 | 0.0010 |
| 15/∼137 kb to FOXB1 | 58222638 | rs6494167 | 1.3 | 0.065 |
| 19/NPHS1 | 41030902 | rs392702 | 0.7 | 0.0135 |
aReflects the additive effect of each SNP with APOL1 risk (recessive).
All models adjusted for age, gender and proportion of African ancestry.