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. 2013 Oct 24;29(3):587–594. doi: 10.1093/ndt/gft423

Table 4.

Interaction effect between the 14 SNPs and APOL1 in the family-based cohort (age, gender and African ancestry adjusted)

Chromosome (nearest gene) Position SNP Outcome Additive
 Dominant
 Recessive
Parameter P-value Parameter P-value Parameter P-value
1 NPHS2 17779554 rs16854341 Kidney disease −0.4 0.44 −0.4 0.44 −1.9 0.08
17779554 rs16854341 Log(UACR + 1) −0.5 0.06 −0.63 0.05 −0.28 0.73
1 SDCCAG8 24156493 rs2802723 Kidney disease 0.3 0.84 0.73 0.11 −0.47 0.38
24156493 rs2802723 Log(UACR + 1) 0.46 0.07 0.63 0.03 −0.16 0.85
7 ∼381 kb to POM12IL12 52689925 rs7810220 Kidney disease −1.5 0.24 −0.46 0.33 0.48 0.17
52689925 rs7810220 Log(UACR + 1) 0 1.00 0.14 0.65 −0.62 0.34
7 ∼238 kb to PTPRZ1 12106246 rs10253361 Kidney disease −2.18 0.04 −0.44 0.34 1.04 0.01
12106246 rs10253361 Log(UACR + 1) −0.02 0.93 0.26 0.39 −1.49 0.02
8 ∼174 kb to STC1 23942506 rs1586171 Kidney disease 0.29 0.80 −0.59 0.25 0.23 0.60
23942506 rs1586171 Log(UACR + 1) −0.2 0.46 −0.38 0.23 0.56 0.47
8 ∼44 kb to TRIB1 12656349 rs4457349 Kidney disease −0.04 0.94 −0.38 0.40 0.15 0.52
12656349 rs4457349 Log(UACR + 1) −0.04 0.85 −0.02 0.94 −0.09 0.80
9 ∼447 kb to TLE4 80929505 rs11138082 Kidney disease −0.25 0.87 −0.57 0.22 −1 0.13
80929505 rs11138082 Log(UACR + 1) −0.27 0.28 −0.46 0.13 0.37 0.59
10 ∼175 kb to GPR26 12525091 rs7897598 Kidney disease −1.18 0.33 −0.59 0.19 −0.83 0.03
12525091 rs7897598 Log(UACR + 1) −0.38 0.09 −0.58 0.04 −0.14 0.78
13 ENOX1 43050726 rs9533534 Kidney disease 0.29 0.65 0.17 0.71 −0.26 0.32
43050726 rs9533534 Log(UACR + 1) 0.06 0.76 −0.13 0.65 0.44 0.26
13 ∼54 kb to SUCLA2 47361123 rs7986369 Kidney disease 0.19 0.71 0 1.00 0.22 0.28
47361123 rs7986369 Log(UACR + 1) 0.19 0.36 0.22 0.50 0.3 0.39
14 LOC728755 27053341 rs12587505 Kidney disease −0.15 0.80 0.56 0.23 0.41 0.07
27053341 rs12587505 Log(UACR + 1) 0 1.00 0.12 0.69 −0.18 0.64
14 ∼8 kb to BMP4 53501324 rs8014363 Kidney disease 0.5 0.46 0.38 0.41 0.43 0.09
53501324 rs8014363 Log(UACR + 1) 0.15 0.50 0.07 0.81 0.48 0.31
15 ∼137 kb to FOXB1 58222638 rs6494167 Kidney disease −1.27 0.09 0.11 0.82 −0.41 0.11
58222638 rs6494167 Log(UACR + 1) −0.12 0.56 0 0.99 −0.38 0.29
19 NPHS1 41030902 rs392702 Kidney disease −0.3 0.76 0.05 0.90 0.38 0.32
41030902 rs392702 Log(UACR + 1) −0.11 0.62 −0.14 0.63 −0.13 0.82

Kidney disease - MDRD eGFR < 60 mL/min/1.73 m2 and/or urine albumin:creatinine ratio (UACR) > 30 mg/g.