Figure 6. In vivo treatment efficiency including ultrasound (US), and CuDox-LTSLs with and without US in NDL tumor mice.

a) Tumor growth as a function of days post-treatment over 28-day treatment cycle presented as percent tumor growth. Initial tumor diameter was ~4 mm. Each mouse was injected intravenously with either saline or liposomal doxorubicin (~6 mg doxorubicin/kg body weight equivalent to ~33 mg/m²) and compared to control animals that received iv injection of saline. For treatment with ultrasound-mediated hyperthermia, one tumor per animal was insonified at 42°C for 5 min prior to and 20 min post-injection. b) Kaplan-Meier survival plot. Statistical analyses were performed using one-way ANOVA followed by the Tukey Post Hoc test. *p<0.05 and ***p<0.001.