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. 2014 Feb 28;9(2):e87140. doi: 10.1371/journal.pone.0087140

Figure 5. Tempol increases survival of mice in a cerebral malaria model.

Figure 5

Comparison with other antioxidants. Plasmodium berghei Anka strain parasitized red blood cells (106) were injected in mice intraperitoneally (i.p.). Then, A, Tempol (20 mg/kg, n = 40), B, PBN (50 mg/kg, n = 10), C, MnTE-2-PyP (5 mg/kg, n = 10), D, MnTBAP (10 mg/Kg, n = 10), E, Mitotempo (3 mg/Kg, n = 10), F, Mitoquinone (10 mg/Kg, n = 10), G, M30 (7.5 mg/kg, n = 10), and H, Epigallocatechin gallate (25 mg/kg, n = 10), were injected i.p. starting from day 1 (all reagents) or day 4 p.i. (for Tempol only) as indicated. One hundred µL of each antioxidant was injected i.p. daily/mice. The percent of non-treated and treated mice that survived over time is given in Kaplan–Meier curves. *, P≤0.05 (Log-rank test). NS, non-significant.