Figure 8. Cerebral malaria in mice deficient for NADPH oxidase or SOD1 or in the presence of DETC or DPI.
Plasmodium berghei Anka parasitized red blood cells (106) were injected intraperitoneally (i.p.) into A, mice knocked out (KO) for NADPH oxidase or controls (n = 8). B, An aliquot of blood was collected at day 6 to determine parasitemia. C, P. berghei Anka infection of mice KO for SOD1 (n = 8). D, An aliquot of blood was collected at day 6 to determine parasitemia. E, P. berghei Anka infection of mice treated with SOD inhibitor, DETC (100 µL, 50 mg/Kg) (n = 10). F, An aliquot of blood was collected at day 6 to determine parasitemia. G, P. berghei Anka infection of mice treated with NADPH oxidase inhibitor, DPI (100 µl, 2 mg/Kg)(n = 10). H, An aliquot of blood was collected at day 6 to determine parasitemia. *, P≤0.05 (Log-rank test). NS, non-significant.