Table 1. Associations of ABO gene in 9q32 with P-LIP and ACE in Takahata and Yamagata populations.
SNPs (position) | minor | P-LIP | ACE | ||||||||
stage* | allele | MAF | beta** | SE | p value | ARS*** | beta** | SE | p value | ARS*** | |
rs4363269 | 1st | G | 0.287 | −0.0335 | 0.481 | >1e-7 | - | −1.96 | 0.213 | 1.50e-19 | 0.064 |
(136123840) | 2nd | G | 0.269 | −0.242 | 0.511 | >1e-7 | - | −1.93 | 0.180 | 4.58e-26 | 0.071 |
rs8176749 | 1st | A | 0.161 | 4.38 | 0.575 | 5.30e-14 | 0.065 | 2.53 | 0.260 | 1.00e-21 | 0.072 |
(136131188) | 2nd | A | 0.188 | 5.14 | 0.576 | 1.11e-18 | 0.074 | 2.19 | 0.208 | 2.69e-25 | 0.066 |
rs8176746 | 1st | A | 0.167 | 4.35 | 0.568 | 3.89e-14 | 0.067 | 2.55 | 0.255 | 1.34e-22 | 0.075 |
(136131322) | 2nd | A | 0.198 | 5.44 | 0.562 | 1.33e-21 | 0.083 | 2.16 | 0.204 | 1.79e-25 | 0.068 |
rs2073824 | 1st | G | 0.496 | 1.35 | 0.430 | >1e-7 | - | 1.15 | 0.193 | 4.00e-9 | 0.031 |
(136132633) | 2nd | A | 0.475 | −1.85 | 0.462 | >1e-7 | - | −1.06 | 0.167 | 2.96e-10 | 0.030 |
rs657152 | 1st | A | 0.440 | 2.66 | 0.424 | 5.13e-10 | 0.056 | −0.554 | 0.196 | >1e-7 | - |
(136139265) | 2nd | A | 0.454 | 3.38 | 0.456 | 2.01e-13 | 0.060 | −0.697 | 0.168 | >1e-7 | - |
rs500498 | 1st | A | 0.455 | −2.47 | 0.421 | 6.26e-9 | 0.054 | 0.385 | 0.195 | >1e-7 | - |
(136148647) | 2nd | A | 0.445 | −3.00 | 0.457 | 6.58e-11 | 0.050 | 0.424 | 0.168 | >1e-7 | - |
rs505922 | 1st | G | 0.450 | 2.54 | 0.419 | 1.95e-9 | 0.056 | −0.465 | 0.194 | >1e-7 | - |
(136149229) | 2nd | G | 0.458 | 3.57 | 0.453 | 5.83e-15 | 0.068 | −0.645 | 0.167 | >1e-7 | - |
rs495828 | 1st | A | 0.281 | 0.27 | 0.481 | >1e-7 | - | −2.27 | 0.210 | 4.27e-26 | 0.087 |
(136154867) | 2nd | A | 0.264 | −0.0726 | 0.509 | >1e-7 | - | −2.36 | 0.176 | 8.34e-39 | 0.102 |
rs7025162 | 1st | A | 0.415 | −0.815 | 0.428 | >1e-7 | - | −1.40 | 0.192 | 5.37e-13 | 0.044 |
(136166346) | 2nd | A | 0.398 | −0.695 | 0.467 | >1e-7 | - | −1.26 | 0.167 | 7.55e-14 | 0.039 |
*1st population from the Takahata cohort, 2nd from the Yamagata cohort.
**Regression coefficient.
***Degrees of freedom adjusted R squared.