Table 3. Antagonistic pleiotropism of ABO gene in 9q32 with ACE/P-LIP in Takahata and Yamagata populations.
| SNPs (position) | minor | ACE/P-LIP | |||||
| stage* | allele | MAF | beta** | SE | p value | P-gain | |
| rs4363269 | 1st | G | 0.287 | −0.0869 | 0.012352 | 3.33e−12 | 1.26e+11 |
| (136123840) | 2nd | G | 0.269 | −0.0984 | 0.012118 | 9.26e−16 | 9.62e+14 |
| rs8176749 | 1st | A | 0.161 | 0.022 | 0.016694 | >0.05 | 1.03e−15 |
| (136131188) | 2nd | A | 0.188 | 0.002 | 0.014242 | >0.05 | 1.14e−24 |
| rs8176746 | 1st | A | 0.167 | 0.023 | 0.016458 | >0.05 | 2.61e−16 |
| (136131322) | 2nd | A | 0.198 | −0.0054 | 0.013962 | >0.05 | 1.24e−24 |
| rs2073824 | 1st | G | 0.496 | 0.024 | 0.012196 | >0.05 | 2.20e−2 |
| (136132633) | 2nd | A | 0.475 | −0.0192 | 0.011215 | >0.05 | 1.79e−4 |
| rs657152 | 1st | A | 0.440 | −0.0814 | 0.011028 | 2.84e−13 | 1.75e+10 |
| (136139265) | 2nd | A | 0.454 | −0.1013 | 0.009994 | 1.80e−23 | 1.47e+18 |
| rs500498 | 1st | A | 0.455 | 0.073 | 0.010976 | 4.00e−11 | 1.16e+9 |
| (136148647) | 2nd | A | 0.445 | 0.089 | 0.010965 | 1.26e−15 | 7.07e+12 |
| rs505922 | 1st | G | 0.450 | −0.0767 | 0.010916 | 3.42e−12 | 4.74e+9 |
| (136149229) | 2nd | G | 0.458 | −0.1038 | 0.009933 | 8.67e−25 | 9.48e+19 |
| rs495828 | 1st | A | 0.281 | −0.1077 | 0.012212 | 3.80e−18 | 4.24e+16 |
| (136154867) | 2nd | A | 0.264 | −0.1146 | 0.01097 | 8.50e−25 | 5.99e+23 |
| rs7025162 | 1st | A | 0.415 | −0.0469 | 0.012084 | 1.1e−4 | 5.55e+2 |
| (136166346) | 2nd | A | 0.398 | −0.0462 | 0.011234 | 4.11e−5 | 8.19e+2 |
*1st population from the Takahata cohort, 2nd from the Yamagata cohort.
**Regression coefficient.