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. 2014 Feb 28;9(2):e89561. doi: 10.1371/journal.pone.0089561

Figure 1. Incidence of diabetes in NOD congenic mouse strains undergoing anti PDL1 treatment.

Figure 1

Treatment was started at 10 weeks of age. a): Incidence of diabetes in Idd5 and sub-congenics Idd5.1, Idd5.2, Idd5.3 and Idd5.2/5.3 until day 30 after anti PDL1 treatment. In Idd5 mice (n = 16) 62.5% developed diabetes, in Idd5.1 (n = 15) 66.6%, in Idd5.2 (n = 20) 80%, in Idd5.3 (n = 8) 87.5% and in Idd5.2/5.3 (n = 23) 66.5%. NOD mice (n = 28) had a 92.5% incidence of diabetes by day 30. All control treated mice did not develop diabetes. b): In Idd9 (n = 26) 46.15% developed diabetes, in Idd9.1 (n = 20) 95%, in Idd9.2 (n = 30) 56.6% and in Idd9.3 (n = 21) 90.5%. c): Idd3 (n = 17) developed diabetes at a rate of 50%, Idd10/18 (n = 18) at 94.1%, Idd3/10/18 (n = 26) at 30.8%. d): In Idd3/5 (n = 16) 0% of anti - PDL1 treated mice developed diabetes, in Idd3/5.2/5.3 (n = 13) 15.4%. Statistics and cumulative incidence for the strains are shown in separate Tables for Figure 1. P-values were calculated using Log-rank (Mantel-Cox test).