Table 2. Spontaneous incidence of type 1 diabetes at 7 months of age compared to anti PDL1 treatment of 10 week old mice.
Strain | Line | Cumulative Incidence of spontaneous type 1 diabetes | Cumulative Incidence of type 1 diabetes with aPDL1 treatment starting at 10 weeks |
NOD.B10-Idd5.1 | 1094 | 40% | 62.5% |
Idd5.2 Idd5.3 | |||
NOD.B10-Idd5.1 | 2193 | 62% | 66% |
NOD.B10-Idd5.2 | 6146 | 38% | 80% |
NOD.B10-Idd5.3 | 6360 | 69% | 90% |
NOD.B10-Idd5.2 | 1595 | 25% | 65% |
Idd5.3 | |||
NOD.B10- | 905 | 3% | 46% |
Idd9.1/9.2/9.3 | |||
NOD.B10-Idd9.1 | 1565 | 35% | 95% |
NOD.B10-Idd9.2 | 1566 | 55% | 56% |
NOD.B10-Idd9.3 | 1106 | 50% | 90% |
NOD.B6-Idd3 | 1098 | 20% | 50% |
NOD.B6- | 7754 | 50% | 94% |
Idd10/Idd18 | |||
NOD.B6-Idd3/10/18 | 1538 | 9% | 31% |
NOD.B6-Idd3 B10- | 6109 | 1% | 0% |
Idd5 | |||
NOD.B6-Idd3 | 7380 | 0% | 15% |
Idd5.2/5.3 | |||
NOD.B6-Idd3 | 9245 | 0% | |
Idd5.2/5.3 | |||
NOD | 70–90% | 93% |